Affiliation:
1. Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur, Rajasthan, India
2. Department of Pharmacy, B.N. University, Udaipur, Rajasthan, India
3. Department of Chemistry, Ganpat University, Mehsana, Gujarat, India
Abstract
:
The present study deals with the synthesis of novel 1-(1,3-benzothiazol-2-yl)-3-chloro-4Hspiro[
azetidine-2,3'-indole]-2',4(1'H)-dione derivatives from the reaction of 3-(1,3-benzothiazol-2-
ylimino)-1,3-dihydro-2H-indol-2-one derivatives with chloroacetyl chloride in the presence of triethylamine
(TEA). The mechanism involved simple acid or base catalysed reaction through the formation of
Schiff base followed by cyclisation via ketene–imine cycloaddition reaction. All synthesized compounds
were characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analysis. The antimicrobial
activities of the synthesized derivatives 5a-5g were examined via Micro Broth Dilution method against
bacterial strains Bacillius subtilis, Staphylcoccus aureus, E. coli, P. aeruginosa, and fungal strain Candida
albicans for determining MIC values. Ampicillin, chloramphenicol, and griseofulvin were used as
standard drugs.
:
The MIC values for antimicrobial activity of synthesized compounds were examined using Micro
Broth Dilution method. Compounds 5a, 5b, and 5c were found effective against E. coli (MTCC 442)
and P.aeruginosa (MTCC 441) and all compounds showed moderate to excellent activity against
Streptococcus aureus (MTCC 96) and Bacillius subtilis (MTCC 441). Regarding the antifungal screening,
compounds 5a, 5b, and 5c exhibited excellent activity against Candida albicans MTCC 227.
1-(1,3-benzothiazol-2-yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-dione derivatives may be
used as potential lead molecules as effective antimicrobial agents.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献