Synthesis of Highly Functionalized Quinazoline-2,4(1H,3H)-diones from Isocyanides, Aniline and Isocyanate via Cu-Catalyzed Intermolecular C-H Activation Reactions
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Published:2020-11-29
Issue:11
Volume:17
Page:832-836
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ISSN:1570-1786
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Container-title:Letters in Organic Chemistry
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language:en
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Short-container-title:LOC
Author:
Nematpour Manijeh1,
Dastjerdi Hossein Fasihi1,
Jahani Mehdi2,
Tabatabai Sayyed Abbas1
Affiliation:
1. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Chemistry, Sharif University of Technology, Tehran, Iran
Abstract
A simple and appropriate procedure for the synthesis of quinazoline-2,4(1H,3H)-dione derivatives
from isocyanides, aniline and isocyanate via the Cu-catalyzed intramolecular C-H activation
reaction is reported. The advantages of this method are one-pot conditions, accessible starting materials-
catalyst, high yield of products, and short reaction times. The structures are confirmed spectroscopically
(1H- and 13C-NMR, IR and EI-MS) and by elemental analyses.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry