Metal-Free Synthesis of Pyrimidinone Derivatives via Biginelli Reaction Using Aqueous NaICl2-Reference-Cited by-同舟云学术

Metal-Free Synthesis of Pyrimidinone Derivatives via Biginelli Reaction Using Aqueous NaICl2

Published:2020-08-18 Issue:8 Volume:17 Page:613-617
ISSN:1570-1786
Container-title:Letters in Organic Chemistry
language:en
Short-container-title:LOC

Author:

Hatvate Navnath T.¹,Ghodse Shrikant M.²,Mundlod Krishna N.¹,Telvekar Vikas N.¹

Affiliation:

1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India

2. Department of Pharmaceutical Chemistry, Prin. K.M. Kundnani College of Pharmacy, Mumbai 400005, India

Abstract

Metal-free synthesis of pyrimidinone (alky/aryl) via Biginelli reaction in the presence of aqueous sodium dichloroiodate (NaICl2) was studied under reflux conditions. Herein, we first time report the synthesis of the aliphatic Biginelli product by using aliphatic aldehyde, cyclopentane, and urea. Several aromatic and heteroaromatic aldehydes were studied for the confirmation of the wide applicability of aq. NaICl2 for the synthesis of corresponding Biginelli products. The obtained desired products provide good to excellent yield.

Funder

(SERB)

UGC

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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