Affiliation:
1. Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management,
SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai - 400056, India
Abstract
Abstract:
In recent years, nanotechnology has gained much attention from scientists for the
obtainment of significant advances in therapeutic potential. Nano-delivery systems have emerged
as an effective way to improve the therapeutic properties of drugs, including solubility, stability,
prolongation of half-life, as well as promoting the accumulation of drug at the target site. The
nanoparticles have also been incorporated into various conventional drug delivery systems. This
review study aims to introduce the amalgamation of nanoparticles into drug carriers. To overcome
the limitations of single nanoparticles, such as toxicity, high instability, rapid drug release as well
as limited drug loading capacity, a multi-component system is developed. Liposomes,
microparticles, nanofibers, dendrimers, etc., are promising drug carriers, having some limitations
that can be minimized, and the compilation of nanoparticles synergizes the properties. The
amalgamated nanocarriers are used for the diagnostic purpose as well as treatment of various
chronic diseases. It also increases the solubility of hydrophobic drugs. However, each system has
its advantages and disadvantages based on its physicochemical properties, efficacy, and other
parameters. This review details the past and present state of development for the fusion of
nanoparticles within drug carriers and future research works are needed for the same.
Publisher
Bentham Science Publishers Ltd.
Subject
Biomedical Engineering,Pharmaceutical Science
Reference137 articles.
1. Siddiqui M.D.N.; Garg G.; Sharma P.K.; A Short Review on “ A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Pa-tents ” Conventional Oral Modified Release Fast Action Oral Solid. Int J Pharm Sci Rev Res 2011,5,291-303
2. Mishra D.M.K.; A Review Article on the Oral Dosage Form: Tablets. World J Pharm Res 2017,6,264-271
3. Gavhane S.A.; The Novel Drug Delivery System. Int Journal of Creative Research Thoughts 2021,9,373-385
4. Bangham A.D.; Horne R.W.; Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J Mol Biol 1964,8(5),660-IN10
5. Sainz V.; Conniot J.; Matos A.I.; Regulatory aspects on nanomedicines. Biochem Biophys Res Commun 2015,468(3),504-510