Peculiarities of Bioaccumulation and Toxic Effects Produced by Nanoparticles of Molybdenum (VI) Oxide under Multiple Oral Exposure of Rats: Examination and Comparative Assessment

Abstract

Introduction: Molybdenum (VI) oxide nanoparticles (MoO3 NPs) are widely used in various economic activities. This creates elevated risks of exposure to this nanomaterial for workers and the population in general, and consequently, there can be an increased number of developing pathological changes caused by exposure to MoO3 NPs. Objective: The study aims to examine and comparatively assess peculiarities of bioaccumulation and toxic effects produced by MoO NPs under multiple oral introductions. Methods: We evaluated the sizes of analyzed particles by scanning electronic microscopy; the specific surface area was calculated by the method of Brunauer, Emmett and Taylor; the total pore volume by Barrett, Joyner and Halenda. Rats were exposed as per the scheme introduced by Lim with colleagues. We examined biochemical and hematological blood indicators, molybdenum concentrations, and pathomorphological changes in tissues of various organs 24 hours after the last exposure. The study involved a comparison with effects produced by MoO3 microparticles. Results: We evaluated the sizes of analyzed particles by scanning electronic microscopy; the specific surface area was calculated by the method of Brunauer, Emmett and Taylor; the total pore volume by Barrett, Joyner and Halenda. Rats were exposed as per the scheme introduced by Lim with colleagues. We examined biochemical and hematological blood indicators, molybdenum concentrations, and pathomorphological changes in tissues of various organs 24 hours after the last exposure. The study involved a comparison with effects produced by MoO3 microparticles. Conclusion: MoO3 NPs are more able to bioaccumulate and produce toxic effects compared with their microdispersed analogue under multiple oral introductions into the body.