Quantum Dots: Next Generation of Smart Nano-Systems

Author:

Jahangir Mohammed Asadullah1,Gilani Sadaf Jamal2,Muheem Abdul3,Jafar Mohammed4,Aslam Mohammed3,Ansari Mohammed Tahir5,Barkat Mohammed Abul6

Affiliation:

1. Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Karimpur, Rajgir, Nalanda- 803116, Bihar, India

2. Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 2014, Aljouf, Saudi Arabia

3. School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India

4. Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam-31441, Saudi Arabia

5. Faculty of Pharmacy and Health Sciences, University Kuala Lumpur, Royal College of Medicine, Perak, Ipoh, Malaysia

6. Department of Pharmaceutics, School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurgaon-122103, Delhi-NCR, India

Abstract

Background: The amalgamation of biological sciences with nano stuff has significantly expedited the progress of biological strategies, greatly promoting practical applications in biomedical fields. Objective: With distinct optical attributes (e.g., robust photostability, restricted emission spectra, tunable broad excitation, and high quantum output), fluorescent quantum dots (QDs) have been feasibly functionalized with manageable interfaces and considerably utilized as a new class of optical probe in biological investigations. Method: In this review article, we structured the current advancements in the preparation methods and attributes of QDs. Furthermore, we extend an overview of the outstanding potential of QDs for biomedical research and radical approaches to drug delivery. Conclusion: Notably, the applications of QDs as smart next-generation nanosystems for neuroscience and pharmacokinetic studies have been explained. Moreover, recent interests in the potential toxicity of QDs are also apprised, ranging from cell investigations to animal studies.

Publisher

Bentham Science Publishers Ltd.

Subject

Biomedical Engineering,Pharmaceutical Science

Reference70 articles.

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3. Tuncer-Degim I.; Kadioglu D.; Cheap, suitable, predict- able and manageable nanoparticles for drug delivery: quantum dots. Curr Drug Deliv 2013,10(1),32-38

4. Probst C.E.; Zrazhevskiy P.; Bagalkot V.; Gao X.; Quantum dots as a platform for nanoparticle drug delivery vehicle design. Adv Drug Deliv Rev 2013,65(5),703-718

5. Jin Y.; Gao X.; Plasmonic fluorescent quantum dots. Nat Nanotechnol 2009,4(9),571-576

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