Author:
Nettleton Jeremy,Adimonye Anthony,Manley Jonathan,Jelski Joseph,Doherty Warren,Rees Mandy,Patel Biral
Abstract
Tranexamic acid has been shown to be an effective agent in reducing blood loss in various surgical procedures; however, there is a dearth of evidence for its use and potential side effects in urological surgical procedures. This review discusses the pathophysiology of tranexamic acid, its use in traumatic and surgical bleeding and the current evidence for its potential utilisation in urological surgery.
Publisher
Bentham Science Publishers Ltd.
Reference51 articles.
1. Shakur H, Roberts I, Bautista R, et al.
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial.
Lancet
2010;
376
(9734)
: 23-32.
2. Ker K, Edwards P, Perel P, Shakur H, Roberts I.
Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis.
BMJ
2012;
344
: e3054.
3. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): An international, randomised, double-blind, placebo-controlled trial.
Lancet
2017;
389
(10084)
: 2105-16.
4. Sprigg N, Flaherty K, Appleton J, et al.
TICH-2 Investigators Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial
2018.
Available from: www.thelancet.com
5. Roberts I, Coats T, Edwards P, Gilmore I, Jairath V, Ker K, et al.
HALT-IT-tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial.
Trials
2014;
15
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献