Affiliation:
1. Centre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur,
Malaysia
Abstract
Abstract:
Natural products contain bioactive compounds that are produced naturally via synthetic or
semisynthetic processes. These bioactive compounds play significant biological roles, especially for
growth as well as in defense mechanisms against pathogens. Bioactive compounds in natural products
have been extensively studied in recent decades for their pharmacological activities, such as anticancer,
wound healing, anti-microbial, anti-inflammatory, and anti-oxidative properties. However, their
pharmaceutical significance has always been hindered by their low bioavailability and instability with
variations in pH, temperature, and exposure to light. Nanotechnology paves the way for the development
of drug delivery systems by enhancing therapeutic efficacy. Nanostructured lipid carriers, a lipidbased
drug delivery system, are recently being studied to improve the biocompatibility, biodegradability,
bioavailability, solubility, permeability, and shelf life of bioactive compounds in the pharmaceutical
industry. The ideal component and preparation method for bioactive compounds in nanostructured lipid
carrier development is necessary for their physicochemical properties and therapeutic efficiency. Therefore,
this review seeks to highlight recent developments, preparation, and application of nanostructured
lipid carriers as carriers for natural bioactive compounds in improving their therapeutic potential in
drug delivery systems.
Funder
Ministry of Higher Education, Malaysia
Publisher
Bentham Science Publishers Ltd.
Reference110 articles.
1. Xie T.; Song S.; Li S.; Ouyang L.; Xia L.; Huang J.; Review of natural product databases. Cell Prolif 2015,48(4),398-404
2. Gil M.I.; Amodio M.L.; Colelli G.; CA/MA on Bioactive Compounds. Controlled and Modified Atmospheres for Fresh and Fresh-Cut Produce 2020
3. Galanakis C.M.; Nutraceutical and functional food components: Effects of innovative processing techniques 2017
4. Shukla D.; Rawal R.; Jain N.; A brief review on plant-derived natural compounds as an anti-cancer agents. Int J Herb Med 2018,6(5),28-36
5. Georgescu M.; Marinas O.; Popa M.; Stan T.; Lazar V.; Bertesteanu S.V.; Chifiriuc M.C.; Natural compounds for wound healingWorldwide Wound Healing - Innovation in Natural and Conventional Methods 2016
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