Affiliation:
1. Institute of Pharmaceutical Research, GLA University, Mathura -281406, India
Abstract
Abstract:
Cancer is one of the most lethal diseases of the twenty-first century. Many medicines, including
antitumor antibiotics, deliver tedious and severe chemotherapy and radiation treatment, both of
which have significant side effects. DNA nanorobots, as an alternative, might be used as a cancer treatment
method that is both safer and more precise than current treatments. DNA nanobots are being
praised as a major milestone in medical research. The major goal of these nanobots is to find and destroy
malignant cells in the human body. A unique strand of DNA is folded into the systematic form to
create these nanobots. DNA origami has magnified passive tumor-targeting and prolonged properties at
the tumor location. The triangle-like DNA origami, in particular, shows excellent accumulation on passive
targeting of the tumor. Self-built DNA origami nanostructures were utilized to deliver the anticancer
drug doxorubicin into tumors, and the approach was found to be highly successful in vivo. In
another demonstration, a robot was made with the help of DNA origami and aptamer for folding a 90nm
long tube-like apparatus. It was carried out to transport the blood coagulation protease thrombin in the
interior portion guarded against blood plasma protein and circulating platelets. The robot unfolded once
the aptamer was identified and attached to its tumor-specific target molecule, delivering thrombin to the
circulation, stimulating coagulation of the regional malignant cells, and proceeding to tumor necrosis
and tumor growth inhibition. Various studies revealed the effectiveness of DNA nanobots in cancer
therapy.
Publisher
Bentham Science Publishers Ltd.
Cited by
4 articles.
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