A Comprehensive Review on Recently Detected Herbal Phytoactives Having Anti-Diabetic Potential for Various Diabetes-Related Complications

Abstract

Background: Diabetes is a metabolic, endocrine disorder which is featured by hyperglycemia and glucose intolerance, primarily due to beta cell destruction, with Insulin Resistance playing a secondary role. It is treated with the help of many chemical based drugs as well as natural derivatives. Objective: There is urgent need to develop new efficacious, cheaper and more available drugs to face this growing public health challenge. Many anti-diabetic drugs are often often associated with many adverse effects. Materials & Methods: Literature was reviewed in a narrative manner in order to pertain the information about active phytoactives present in the different plants. Anti-diabetic drugs are often loaded with side effects; therefore, review is being done for the selection of effective natural therapeutic moieties with less or no adverse effects. Results: In this review article, we described the detailed review of recently detected bioactive compounds present in different natural substances; which can be used effectively for diabetes related adversities. Conclusion: Natural products based bioactive molecules have been proven to improve insulin resistance and other related complications through suppression of inflammatory signaling pathways.