Affiliation:
1. Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India
Abstract
Background:
Vitex negundo Linn. commonly known as five leave chase tree is an
ethnobotanically important drug in traditional system of medicine. The plant is widely distributed
in India, China and other Asian and American countries.
Objective:
The review aims at presenting comprehensive information with respect to ethnopharmacological
relevance and recent findings on phytochemical and biological activities
of Vitex negundo.
Method:
Literature was collected from various sources such as pubmed, scopus, science direct,
and others.
Results:
Extracts and secondary metabolites of this plant, particularly those from roots and
leaves, possess useful pharmacological activities such as anti-inflammatory, antitumor, antioxidant,
antimicrobial, galactagogue, antigastric, antiflatulant, antiparasitic, analgesic, hepatoprotective
and antihypertensive, some of which have been validated scientifically. All parts
of the plant especially leave and roots contain a large number of bioactive phytoconstituents
including flavonoids, iridoids, lignans, volatile oil, terpenes, coumarins, phenolic and steroidal
compounds which impart multiple medicinal properties. Vitexin, isovitexin, viridifol,
caffeic acid, chlorogenic acid and isochlorogenic acid are the main components.
Conclusion:
The review emphasizes the medicinal importance of Vitex negundo and its bioactive
constituents in the traditional system of medicine.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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