Affiliation:
1. Research & Development,
Tabib Daru Pharmaceutical Company, Kashan, Iran
2. Aerospace Research Institute, Ministry of Science, Research and Technology, Tehran, Iran
Abstract
Abstract:
Ferula asafoetida is an endemic species in Iran and is rich in oleo-gum resin with high
economic value in the world. One important application of F. assafoetida is its traditional use for
the management of respiratory ailments. The aim of this review was to collect papers dealing with
F. asafoetida oleo-gum resin in respiratory tract’s diseases in modern medicine. For preparing the
manuscript the scientific databases (Google scholar, PubMed, Springer, Science Direct, Magiran),
books, thesis, etc. were searched using the keywords of “Ferula asafoetida”, “Ferula scorodesma”,
“Scorodesma foetida”, “Northex asafoetida” plus “respiratory tract”, "respiratory disorder" “infection”,
“cough”, “trachea”, “traditional medicine” up to Feb 2022 and the collected data were summarized,
analyzed, and discussed. The results of the investigation confirmed the traditional belief on
the efficacy of Ferula asafoetida in the treatment of respiratory viral infection (Coronavirus, influenza),
cigarette smoking, asthma, cough and cancer, but most studies were limited to in vitro. There
was only one registered randomized, blinded, placebo controlled clinical trial for 300 mg F. asafoetida
aqueous extract capsules (three times a day for 14 days) on 40 patients with COVID-19 without
any published results. Although, the studies implied the efficacy of F. asafoetida in the treatment of
respiratory treatments, but design large clinical studies for evaluating its efficacy and safety is essential
in future investigations.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery