A Review on Valeriana wallichii: Chemical Composition and Pharmacological Research

Author:

Husain Syed Akhtar1,Jamal Ghosia1,Parveen Rabea12,Khan Mohammad Aasif13,Srivastava Varsha2,Mustafa Saad4,Ahmad Sayeed2

Affiliation:

1. Human Genetics Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India

2. Centre of Excellence in Unani Medicine (Pharmacognosy & Pharmacology), Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India

3. Department of Medical Hematology and Medical Oncology, School of Medicine, Mays Cancer Centre, UT Health Science Centre, San Antonio, TX, USA

4. School of Environmental Sciences, Jawahar Lal Nehru University, New Delhi 110067, India

Abstract

Background: In the past decade, a rising trend has seen in the use of plant-based medicines because of fewer/no side effects. Plants are always the major source of traditional medicines in every culture. The main objective of this review is to shed a light on phytochemical composition and pharmacological research of Valeriana wallichii. Methods: Electronic databases like Google Scholar, PubMed, Scopus, etc., were searched for traditional uses, extraction of phytoconstituents, therapeutical uses and pharmacology of V. wallichii. Results: V. wallichii has been used as a sleep remedy since ancient times in the Indian traditional system of medicines. It is also used as diuretic, spasmolytic and pain relieving agent. It is used for the treatment of epilepsy, dyspeptic symptoms, failing reflexes, habitual constipation, insanity, nervous debility, obesity, spastic disorders, and in snake poisoning, and also reported to have cytotoxic potential. The pharmacological activity of the plant is due to presence of different types of secondary metabolites, including valerianic acid, valerosidatum glycoside, valepotriates, dihydrovaltrate, 6-methylapigenin, hesperidin, sesquiterpenoids, bornylisovalerianate, isovalerenic acid, 1-camphene, 1-pinene, terpineol, valerianine, bornylisovalerianate, valerianine and so on. This review focuses on detailed phytochemistry of the plant and its therapeutic indication. The main emphasis is given on anticancer potential of V. wallichii, with in vitro cytotoxic as well as in vivo antitumor description. Conclusion: The review reveals that further research, as well as clinical trials, are needed to know this plant as an effective drug for the treatment of cancer in future with exact molecular mechanisms.

Publisher

Bentham Science Publishers Ltd.

Subject

Complementary and alternative medicine,Drug Discovery

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