Affiliation:
1. Bioactive Natural Product Laboratory, Department of Pharmacognosy & Phytochemistry, School of
Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-110062, India
2. Human Genetics Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi-110025, India
3. Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi-
110062, India
Abstract
Abstract:
Vitex negundo is a traditional herb known for its medicinal properties in Unani, Ayurveda,
Siddha, Chinese, Roman, and other traditional systems of medicine. Traditionally, it is used as
anthelminthic, antitoxin, aphrodisiac, contraceptive, antimalarial, analgesic, antiinflamatory, antiasthmatic,
vermifuge, etc. All parts of V. negundo contain a number of phytoconstituents like alkaloids,
fatty acids, flavonoids, glycosidic irridoids, lignans, phenols, steroids, tannins and di- and sesquiterpenes.
Due to the presence of a variety of secondary metabolites, V. negundo is used in different
types of diseases or disorders by traditional practitioners for the treatment of spermatorrhoea,
stomachache, asthma, cold, diarrhoea, indigestion, gallstone, hernia, eye disorders, rheumatism, irritable
bladder and dysmenorrhea, headache, migraine, kwashiorkor, neck gland sores, tubercular
neck swelling, reddened, arthritis, jaundice, urticaria, eczema and liver disorders. It is most widely
used for curing disorders of the reproductive system like vital power, depression, frail erection
without libido, self-contempt for sexual abuse, stool containing prostatic fluid, and testicle pain.
Facts were gathered from databases such as PubMed, Google Scholar, Springer, Scopus, and ScienceDirect,
as well as literature found in books on medicinal plants. It has recently been reported to
have cytotoxic properties against various types of cancer cells. It works by inducing apoptosis via
the mitochondrial and TRIAL pathways and stopping the cell cycle. This review sheds light upon
the ethnomedicinal uses, phytochemistry, different extraction procedures, and pharmacology of V.
negundo. In conclusion, it was found that this traditional herb had an emerging past, exciting present
and promising future for the treatment of several diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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