Affiliation:
1. Department of Chemistry, Govt. Raza P.G. College, Rampur-244901, UP, India
2. Department of Chemistry, University of Allahabad-211002, UP, India
3. Department of Biotechnology, Era's Lucknow Medical College, Era University, Lucknow-226003, UP, India
4. Department of Botany, D.N. (PG) College, Meerut-200005, UP, India
Abstract
Background:
Cupressus sempervirens (C. sempervirens), commonly known as
Mediterranean cypress is native to the eastern Mediterranean region, North America and
subtropical Asia at higher altitudes. The crude, semi-purified and purified extracts of
C. sempervirens have long been recognized for its pharmacological activities as evidenced
by its extensive use by indigenous cultures in herbal medicines, tonics and infusion. Pharmacological
properties displayed the prodigious biological activities that could be further
explored for development of new herbal formulations or therapeutic agents.
Aims:
This review presents a critical analysis of the current state of knowledge about the
ethno medicinal uses, phytochemistry and pharmacological properties of C. sempervirens L
and its future applications.
Materials and Methods:
Literature related to C. sempervirens and its synonyms were
searched on the available online literature databases such as Google Scholar, PubMed,
SciFinder, Scopus, Springer, ScienceDirect, Wiley, ACS, Scielo and Web of Science, thesis,
dissertations, books, reports, local herbal encyclopedias and other relevant websites.
Results:
A review of literature showed that decoction of cones and young branches of C.
sempervirens gave astonishing effect in the treatment of hemorrhoids and to treat excessive
sweating in the feet. Enormous pharmacological properties have been found including antiseptic,
anti-inflammatory, antispasmodic, antioxidant, antimicrobial, hepatoprotective,
wound-healing, anticoagulant, antihyperlipidemic, anticancer, neurobiological, antidiabetic,
and antiosteoporotic. Approximately 109 phytochemical constituents have been searched out
as isolates from various parts of this plant comprising mostly diterpenoids and biflavonoids.
Conclusion:
Numerous in vivo and in vitro studies have provided support for the traditional
uses of C. sempervirens but further research work is required towards isolating more active
constituents and for validating its clinical utilization in the herbal formulations for humans
as well as investigating any potential toxicity for future clinical studies.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
Cited by
5 articles.
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