Affiliation:
1. CCRAS-RARIDD, Aamkho, Gwalior (M.P.) 474009, India
2. Department of Biotechnology, Lovely Professional University, Punjab 144111, India
3. Department of Biotechnology, KRG, Collage, Gwalior 474009, India
4. Central Council for Research in Ayurvedic Sciences (CCRAS), New Delhi 110058, India
Abstract
Holoptelea integrifolia Roxb. Planch (HI) has been used to treat various ailments
including obesity, osteoarthritis, arthritis, inflammation, anemia, diabetes etc. To review the
major phytochemicals and medicinal properties of HI, exhaustive bibliographic research was
designed by means of various scientific search engines and databases. Only 12 phytochemicals
have been reported including biologically active compounds like betulin, betulinic acid,
epifriedlin, octacosanol, Friedlin, Holoptelin-A and Holoptelin-B. Analytical methods including
the Thin Layer Chromatography (TLC), High-Performance Thin Layer Chromatography
(HPTLC), High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography
With Mass Spectral (LC-MS) analysis have been used to analyze the HI. From medicinal
potency point of view, these phytochemicals have a wide range of pharmacological
activities such as antioxidant, antibacterial, anti-inflammatory, and anti-tumor. In the current
review, it has been noticed that the mechanism of action of HI with biomolecules has not
been fully explored. Pharmacology and toxicological studies are very few. This seems a
huge literature gap to be fulfilled through the detailed in-vivo and in-vitro studies.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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