Affiliation:
1. School of Basic Medical, Yunnan University of Chinese Medicine, Kunming, China
2. The First Affiliated Hospital of
Yunnan University of Chinese Medicine, Kunming, China
Abstract
Abstract:
Tumor is a serious threat to human health, with extremely high morbidity and mortality
rates. However, tumor treatment is challenging, and the development of antitumor drugs has always been a significant research focus. Plant polysaccharides are known to possess various biological activities. They have many pharmacological properties such as immunomodulation, antitumor, antiviral, antioxidative, antithrombotic, and antiradiation effects, reduction of blood pressure and blood sugar levels, and protection from liver injury. Among these effects, the antitumor
effect of plant polysaccharides has been widely studied. Plant polysaccharides can inhibit tumor
proliferation and growth by inhibiting tumor cell invasion and metastasis, inducing cell apoptosis,
affecting the cell cycle, and regulating the tumor microenvironment. They also have the characteristics of safety, high efficiency, and low toxicity, which can alleviate, to a certain extent, the adverse reactions caused by traditional tumor treatment methods such as surgery, radiotherapy, and
chemotherapy. Therefore, this paper systematically summarizes the direct antitumor effects of
plant polysaccharides, their regulatory effects on the tumor microenvironment, and intervening
many common high-incidence tumors in other ways. It also provides data support for the administration of plant polysaccharides in modern tumor drug therapy, enabling the identification of new
targets and development of new drugs for tumor therapy.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Cancer Research,Drug Discovery,Oncology,General Medicine
Cited by
1 articles.
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