Affiliation:
1. School of Business Administration, Shenyang Pharmaceutical University, Shenyang,China
Abstract
Background:
Lung cancer is the most common malignant cancer worldwide. Targeted
therapies have emerged as a promising treatment strategy for lung cancers.
Objective:
To evaluate the current landscape of targets and find promising targets for future new
drug discovery for lung cancers, this research identified the science-technology-clinical development
pattern and mapped the interaction network of targets.
Methods:
Targets for cancers were classified into 3 groups based on a paper published in Nature.
We searched for scientific pieces of literature, patent documents and clinical trials of targets in
Group 1 and Group 2 for lung cancers. Then, a target-target interaction network of Group 1 was
constructed, and the science-technology-clinical (S-T-C) development patterns of targets in Group
1 were identified. Finally, based on the cluster distribution and the development pattern of targets
in Group 1, interactions between the targets were employed to predict potential targets in Group 2
for drug development.
Results:
The target-target interaction (TTI) network of group 1 resulted in 3 clusters with different
developmental stages. The potential targets in Group 2 are divided into 3 ranks. Level-1 is the first
priority and level-3 is the last. Level-1 includes 16 targets, such as STAT3, CRKL, and PTPN11,
that are mostly involved in signaling transduction pathways. Level-2 and level-3 contain 8 and 6
targets, respectively, related to various biological functions.
Conclusion:
This study will provide references for drug development in lung cancers, emphasizing
that priorities should be given to targets in Level-1, whose mechanisms are worth further exploration.
Funder
Discipline Construction of School of Business Administration of Shenyang Pharmaceutical University
National Medical Products Administration Drug Regulatory Scientific Research Base-Drug Regulatory Science Research Institute of Shenyang Pharmaceutical University
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Cancer Research,Drug Discovery,Oncology,General Medicine
Cited by
3 articles.
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