Affiliation:
1. Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil
2. Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Natal, Brazil
Abstract
Objective:
This paper aims to review studies regarding side effects found during Non-
Hodgkin Lymphoma treatment, to suggest the drug class most associated with these effects, as
well as the most prevalent side effect grade.
Methods:
This review is registered in PROSPERO (IDCRD42022295774) and followed the PICOS
strategy and PRISMA guidelines. The search was carried out in the databases PubMed/
MEDLINE, Scientific Electronic Library Online, and DOAJ. Medical Subject Headings Terms
were used and quantitative studies with conclusive results regarding side effects during the
non-Hodgkin lymphoma treatment were selected. Patent information was obtained from google
patents.
Results:
Monoclonal antibodies were the main drug class associated with side effects during NHL
therapy. The combination of Rituximab (Rituxan®; patent EP1616572B) and iInotuzumab (Besponsa
®; patent EP1504035B3) was associated with a higher incidence of thrombocytopenia (p < 0.05),
while the combination of Rituximab and Venetoclax (Venclexta®; patent CN107089981A) was associated
with a higher incidence of neutropenia (p < 0.05) when compared to Bendamustine combinations
(Treanda™; patent US20130253025A1). Meta-analysis revealed a high prevalence of grade 3-4
neutropenia and thrombocytopenia in men. Finally, Americans and Canadians experienced a higher
prevalence of these side effects, when compared to others nationalities (p < 0.05).
Conclusion:
Patents regarding the use of monoclonal antibodies in NHL treatment were published
in the last year. Monoclonal antibodies associated with neutropenia (grade 3-4) and thrombocytopenia,
especially in North American men treated for NHL, and with an average age of 62 years
demonstrated importance in this study.
Funder
National Council for Scientific and Technological Development
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Cancer Research,Drug Discovery,Oncology,General Medicine