Affiliation:
1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
2. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China
Abstract
Abstract:
mRNA emerged as an attractive therapy modality with the development of mRNA
structure engineering techniques and delivery platforms. mRNA therapeutics, applied for vaccine
therapy, protein replacement therapy, and chimeric antigen receptor (CAR) T cell-based therapy,
has shown huge potential in treating a wide range of diseases, such as cancer and rare genetic diseases,
with successful and exciting preclinical and clinical progress. In mRNA therapeutics, a potent
delivery system is key to the success of its application for disease treatment. Herein, different
types of mRNA delivery strategies, including nanoparticles produced from lipid or polymer materials,
virus-based platforms, and exosome-based platforms, are mainly focused.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Cancer Research,Drug Discovery,Oncology,General Medicine
Cited by
1 articles.
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