Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer

Abstract

Background: Chemotherapeutic drugs are principally intended to treat breast cancer. However, sooner or later in tumor drug resistance developed. These chemo drugs are effectual, but with numerous side effects. Breast cancer care may be extremely difficult since recurring cancer is frequently pre-treated with powerful agents, and cancer cells acquire high resistance to earlier therapies, necessitating the use of alternative and more powerful drugs. Nanoparticles(NPs) as a medication delivery technology can overcome medication resistance in breast cancer and significantly reduce the effective dose. The off-targeted nature of chemo drugs can be resolved by encapsulating or attaching chemo drugs in nanocarrier which targets specifically breast cancer cells. Objectives: In this review, we highlight various chemo drugs for breast cancer and their encapsulation or bioconjugation with nanoparticles for its targeted delivery. Conclusion: Nanoparticles may subsist valuable abet in breast cancer management in this regard. Given that traditional chemotherapy, approaches have been demonstrated to have several side effects and defects during treatment, the NPs-mediated Drug delivery mechanism is a possible contender for replacement as a new technique.