Serum Uric Acid is Independently Associated with Diastolic Dysfunction in Apparently Healthy Subjects with Essential Hypertension
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Published:2018-11-16
Issue:1
Volume:17
Page:99-106
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ISSN:1570-1611
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Container-title:Current Vascular Pharmacology
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language:en
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Short-container-title:CVP
Author:
Georgiopoulos Georgios1, Tsioufis Costas1, Kalos Theodoros1, Magkas Nikos1, Roussos Dimitris1, Chrysohoou Christina1, Sarri Georgia1, Syrmali Kyriaki1, Georgakopoulos Panos1, Tousoulis Dimitrios1
Affiliation:
1. First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece
Abstract
Objectives: Accumulating evidence suggests a direct role of Uric Acid (UA) on Left Ventricular
(LV) diastolic function in chronic kidney disease and Heart Failure (HF) patients. Recently, UA
has been linked to LV Hypertrophy (LVH) and Diastolic Dysfunction (DD) in women with preserved
Ejection Fraction (pEF) but not in corresponding men. We sought to assess if UA could predict indices
of DD in hypertensive subjects with pEF independently of gender.
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Method: We consecutively recruited 382 apparently healthy hypertensive subjects (age: 61.7±10.7,
women: 61.3%, median EF: 64%). In 318 patients in sinus rhythm, LV mass-indexed to body surface
area-was calculated (LVMI). LVH was set as an LVMI >116g/m2 or 96 g/m2 in men and women, respectively.
The ratio of early transmitral peak velocity (E) to the mitral annular early diastolic velocity
(Em) was used as an approximation of mean left atrial pressure (E/Em).
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Results: UA [median (interquartile range): 5.4(2) mg/dl] independently predicted E/Em (adjusted coefficient:
1.01, p =0.026) while an interaction term between gender and UA was no significant (p=0.684).
An ordinal score of DD was calculated taking into account increased E/Em, left atrium dilatation and
LVH. Women with increased UA had 254% increased odds (adjusted OR=2.54, p=0.005) to be classified
in the upper range of the DD score.
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Conclusion: In hypertensive subjects without HF, UA is independently associated with the presence of
DD in both genders and correlates with its severity in women. Further prospective studies are warranted
to evaluate the association of UA with adverse cardiovascular outcomes in high-risk populations such as
HF with pEF.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology
Reference42 articles.
1. Bergamini C, Cicoira M, Rossi A, Vassanelli C. Eur J Heart Fail, Oxidative stress and hyperuricaemia: Pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure.,, 2009, 11,, 444-452, 2. Kanellis J, Kang DH. Semin Nephrol, Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease.,, 2005, 25,, 39-42, 3. Gromadzinski L, Januszko-Giergielewicz B, Pruszczyk P. Adv Clin Exp Med, Hyperuricemia is an independent predictive factor for left ventricular diastolic dysfunction in patients with chronic kidney disease.,, 2015, 24,, 47-54, 4. Johnson RJ, Kang DH, Feig D. Hypertension, Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?,, 2003, 41,, 1183-1190, 5. Borghi C, Rosei EA, Bardin T. J Hypertens, Serum uric acid and the risk of cardiovascular and renal disease.,, 2015, 33,, 1729-1741,
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