Affiliation:
1. Department of Vascular Surgery, Dedinje Cardiovascular Institute, Belgrade University School of Medicine, 11040 Belgrade, Serbia
2. Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Sciences Vinca, University of Belgrade, Mike Petrovica Alasa 12-14, 11000 Belgrade, Serbia
Abstract
Chronic venous disease (CVeD) is a highly prevalent condition in the general population, and
it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as
varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other
symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that
most frequently compels CVeD patients to seek medical aid. However, there is a substantial discrepancy
between pain severity and clinically detectable signs of CVeD, questioned by several opposing studies.
Further evaluation is needed to clarify this subject, and to analyse whether pain development predicts
objective CVeD progression.
</P><P>
General management of CVeD starts with advising lifestyle changes, such as lowering body mass index
and treating comorbidities. However, the mainstay of treatment is compression therapy, with the additional
use of pharmacological substances. Venoactive drugs proved to be the drugs of choice for symptom
alleviation and slowing the progression of CVeD, with micronized purified flavonoid fraction being
the most effective one. Interventional therapy is reserved for advanced stages of the disease.
Funder
Ministry of Science, Republic of Serbia
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献