Association Between Telomere Length and Cardiovascular Risk: Pharmacological Treatments Affecting Telomeres and Telomerase Activity-Reference-Cited by-同舟云学术

Association Between Telomere Length and Cardiovascular Risk: Pharmacological Treatments Affecting Telomeres and Telomerase Activity

Published:2022-11 Issue:6 Volume:20 Page:465-474
ISSN:1570-1611
Container-title:Current Vascular Pharmacology
language:en
Short-container-title:CVP

Author:

Zafirovic Sonja¹^ORCID,Macvanin Mirjana¹^ORCID,Stanimirovic Julijana¹^ORCID,Obradovic Milan¹^ORCID,Radovanovic Jelena¹^ORCID,Melih Irena²,Isenovic Esma¹^ORCID

Affiliation:

1. Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia

2. Faculty of Stomatology, Pancevo, University Business Academy, 21000 Novi Sad, Serbia.

Abstract

Abstract: Telomeres represent the ends of chromosomes, and they are composed of an extensive number of – TTAGGG nucleotide sequence repeats in humans. Telomeres prevent chromosome degradation, participate in stabilization, and regulate the DNA repair system. Inflammation and oxidative stress have been identified as important processes causing cardiovascular disease and accelerating telomere shortening rate. This review investigates the link between telomere length and pathological vascular conditions from experimental and human studies. Also, we discuss pharmacological treatments affecting telomeres and telomerase activity.

Funder

Ministry of Education, Science and Technological Development of the Republic of Serbia

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,Pharmacology

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