Malignant Pleural Mesothelioma: Socioeconomic and Clinical Aspects

Abstract

Abstract: Pleural malignancy is an aggressive malignancy of the pleural surface and is primarily associated with asbestos exposure. Malignant pleural mesothelioma (MPM) is an invasive form of mesothelioma and resistant to conventional therapy. Recently, it has also been reported that carbon nanotube (CNTs) exposure can induce inflammation and fibrosis of the pleura and induce tumor development pre-clinical model. Although several strategies like immunotherapy (Dendritic cells, immune checkpoint inhibitors, CAR-T cell therapy), and viral therapy are being employed for the management of MPM. However, poor prognosis and limited treatment options make the problem worse. Apart from clinical challenges, industrial and socioeconomic challenges are key factors for the patients as they are mainly industry workers or their associates. This article is focused on industrial, clinical and socioeconomic challenges associated with malignant pleural mesothelioma (MPM) patients and available opportunities.