Clinical Picture, Diagnosis, Management of NEC, and Effects of Probiotics on its Prevention: A Narrative Review-Reference-Cited by-同舟云学术

Clinical Picture, Diagnosis, Management of NEC, and Effects of Probiotics on its Prevention: A Narrative Review

Published:2024-08-08 Issue: Volume:21 Page:
ISSN:1573-3963
Container-title:Current Pediatric Reviews
language:en
Short-container-title:CPR

Author:

Giuseppe De Bernardo¹,Carla ZIello²,Grazia Parisi²,Carolina Vecchione³,Valentina Fattorusso¹,Simona Spadarella¹,Maurizio Giordano⁴,Giuseppe Buonocore⁵,Serafina Perrone⁶

Affiliation:

1. Department of Woman and Child, Buon Consiglio Fatebenefratelli Hospital, Naples, Italy

2. Division of Pediatrics, Department of Transaltional Medical Sciences, University of Naples Federico II, Naples, Italy

3. University of Naples Federico II Department of Transaltional Medical Sciences Naples Italy

4. Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

5. University of Siena Department of Molecular and Developmental Medicine Siena Italy

6. Neonatology Unit, Department of Medicine and Surgery, University of Parma, Pietro Barilla Children's Hospital, Parma, Italy

Abstract

Abstract: Preterm newborns represent a population at risk of developing intestinal dysbiosis as well as being predisposed to sepsis and Necrotizing Enterocolitis. Necrotizing Enterocolitis is a condition burdened by many complications and mortality due to an alteration of the intestinal barrier, an immaturity of the immune system, and intestinal dysbiosis. Low gestational age at birth, low birth weight, and early use of antibiotics are other predisposing factors. Instead, breast milk and probiotics are protective factors in providing intestinal homeostasis and microbiome regulation. In this mini-review, we analysed the protective role of probiotics in the onset of Necrotizing Enterocolitis in preterm populations.

Publisher

Bentham Science Publishers Ltd.