Role of non-coding RNAs in vulvar cancer

Abstract

Abstract: Vulvar cancer is a rare disease of mostly premenstrual women. Although it is a rare disease, vulvar cancer is on the rise among women of reproductive age. Long non-coding RNAs (lncRNAs) are RNAs with more than 200 nucleotides that are not involved in the production of proteins. LncRNAs are actively associated with disease progression in various diseases. However, although the focus or literature on the role of lncRNAs in the progression of different cancers has elucidated their pathophysiology at least partly, vulvar cancer has received much less attention. The present study showed that the majority of lncRNAs studied so far are miRNAs. Some of these miRNAs have been shown to be upregulated, while others have been shown to be downregulated in vulvar cancer. Furthermore, some hypotheses have been introduced to explain the role of these lncRNAs, including their role in targeting p53, HPV, and HMGA2. In this article, we reviewed the role of lncRNAs in the progression, metastasis, development of chemoresistance, diagnosis, and treatment of vulvar cancer.