Affiliation:
1. GIPS, Assam Science and Technology University, Guwahati, 781017, India
2. Pharmacology and Toxicology Laboratory, School of Pharmaceutical Sciences, Girijananda Chowdhury University, Guwahati, 781017, India
Abstract
Background:
Breast cancer incidence and mortality rates are rising worldwide, which presents
a formidable challenge for women. The advancement of targeted drug therapies offers promising
avenues for treatment, but resource constraints prevent their widespread implementation in advanced
clinical trials, highlighting the need for sustained research funding. Nutritional support is critical
in cancer management, affecting key cancer hallmarks. The anti-inflammatory effects of exercise
and a healthy diet are critical in reducing cancer incidence and tumor growth. A comprehensive approach
to breast cancer treatment requires addressing health challenges and psychological symptoms.
Objective:
In this context, we aim to address modifiable risk factors, including nutrition, physical
activity, and psychosocial factors, which can serve as non-pharmacological adjuncts in reducing
breast cancer risk, incidence, and mortality.
Methods:
This study conducted a thorough literature search on breast cancer, nutrition, physical activity,
psychosocial problems, clinical trial/study, mechanisms, in-vitro and in-vivo. The search was
performed using multiple search engines and the main keywords, and only English publications until
August 2023 were included.
Results:
Nutrition plays a critical role in influencing breast cancer risk, but its exact role needs to be
explored. Diet diversity and exercise are recommended to reduce risk, while psychosocial support is
vital for patient well-being.
Conclusion:
In light of rising global breast cancer challenges, our study underscores the urgent need
for enhanced clinical trial availability, exploration of nutrition-cancer links, and refined psychosocial
interventions to comprehensively address prevention and treatment.
Publisher
Bentham Science Publishers Ltd.