Affiliation:
1. Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The
Nilgiris, Tamil Nadu, India
Abstract
Abstract:
Diabetic wound healing is a dynamic medical process that takes place in an environment
within the body that is complex and contains elevated sugar levels, oxygen deprivation,
and cellular oxidative stress. Phloridzin (Phlorizin) is one of the most well-known polyphenols
found in apples because of its anti-inflammatory, antioxidant, antibacterial, antidiabetic, and antiseptic
properties; it can also play a significant part in the healing of diabetic wounds.
The study aimed to investigate the role of phloridzin as an efficient DPP-4 inhibitor with additional
therapeutic effects in diabetic wound healing, as Dipeptidyl Peptidase-4 (DPP-4) expression
increases in response to increases in glucose, Reactive Oxygen Species (ROS), and inflammation.
Phloridzin inhibiting DPP-4 preserves Stromal cell-derived Factor-1α (SDF-1α),
Insulin-like Growth Factor (IGF), and Glucagon-like Peptide-1 (GLP-1), which are possible
DPP-4 substrates involved in wound healing.
The accessible material from systemic searches in PubMed, Scopus, and published articles was
reviewed with no period of limitation.
The in silico study showed strong binding of phloridzin with DPP-4 protein (2P8S); also, in
vitro DPP-4 inhibition assay has shown better inhibition by phloridzin. This study offers new
research directions for examining phloridzin’s capacity to withstand oxidative stress, as well as
for redefining its tactical function as a powerful DPP-4 inhibitor to regulate the process involved
in the healing of diabetic wounds.
Publisher
Bentham Science Publishers Ltd.