Multi-vesicular Liposome and its Applications: A Novel Chemically Modified Approach for Drug Delivery Application

Author:

Ghosal Kajal1ORCID,Pani Ayan2,Chowdhury Totan3,Kundu Abhijeet3,Thomas Sabu4

Affiliation:

1. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India

2. Department of Pharmaceutics, Haldia Institute of Pharmacy, Hatiberia, Haldia, Purba Medinipur, West Bengal, 721657, India

3. Dr. B.C. Roy College of Pharmacy and AHS, Durgapur, 713206, India

4. Department of Chemical Science, International and Inter University Center for Nanoscience and Nanotechnology (IIUCNN), Mahatma Gandhi University, Priyadarshini Hill, Kottayam, 686560, Kerala, India

Abstract

Background: This study aimed to elaborate on all the aspects of multivesicular liposomes, including structure, function, topology, etc. Liposomes are a unique drug delivery system, in which both hydrophilic and hydrophobic drug molecules can be incorporated. Particularly, multivesicular liposomes have more advantages than other liposomes because of their unique structure. This study provides an overview of several works already performed by various researchers in this field. Numerous studies have reported on preparing and evaluating multivesicular liposomes for drug delivery applications. This study summarizes the process of formulating multivesicular liposomes and their application in drug delivery systems and provides details about how to resolve the problem of limited solubility and stability of biomolecules, along with controlled drug release kinetics, with the possibility of loading various drugs. There is no doubt that multivesicular liposome opens new avenues to develop novel drug delivery system for achieving the desired functional performances and expanding the applications in the drug delivery area.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

Reference91 articles.

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5. Kim S.; Turker M.S.; Chi E.Y.; Sela S.; Martin G.M.; Preparation of multivesicular liposomes. Biochim Biophys Acta Biomembr 1983,728(3),339-348

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