Advancement in Beneficial Effects of AVE 0991: A Brief Review

Author:

Deng Yang1ORCID,Ding Wangli1,Peng Qiang2,Wang Wei2,Duan Rui2,Zhang Yingdong2

Affiliation:

1. School of Basic Medicine & Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China

2. Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China

Abstract

Abstract: AVE 0991, a non-peptide analogue of Angiotensin-(1-7) [Ang-(1-7)], is orally active and physiologically well tolerated. Several studies have demonstrated that AVE 0991 improves glucose and lipid metabolism, and contains anti-inflammatory, anti-apoptotic, anti-fibrosis, and anti-oxidant effects. Numerous preclinical studies have also reported that AVE 0991 appears to have beneficial effects on a variety of systemic diseases, including cardiovascular, liver, kidney, cancer, diabetes, and nervous system diseases. This study searched multiple literature databases, including PubMed, Web of Science, EMBASE, Google Scholar, Cochrane Library, and the ClinicalTrials.gov website from the establishment to October 2022, using AVE 0991 as a keyword. This literature search revealed that AVE 0991 could play different roles via various signaling pathways. However, the potential mechanisms of these effects need further elucidation. This review summarizes the benefits of AVE 0991 in several medical problems, including the COVID-19 pandemic. The paper also describes the underlying mechanisms of AVE 0991, giving in-depth insights and perspectives on the pharmaceutical value of AVE 0991 in drug discovery and development.

Funder

National Science and Technology Innovation 2030

Natural Science Foundation of Jiangsu Province

International Joint Research and Development Project of Nanjing

China Postdoctoral Science Foundation

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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