Affiliation:
1. Key Laboratory of Structure-Based Drugs Design and Discovery of Ministry of Education, Shenyang Pharmaceutical
University, Shenyang, China
Abstract
Abstract:
DNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which
plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic
targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important
in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to
validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review,
we summarized the small molecule inhibitors of DNMT3A discovered in recent years and their inhibitory
activities, and classified them based on their inhibitory mechanisms.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
3 articles.
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