Affiliation:
1. Department of Pharmaceutical Chemistry, BN College of Pharmacy, Faculty of Pharmacy, BN University, Udaipur, Rajasthan-313001, India
Abstract
Triazine is the six-membered heterocyclic ring containing three nitrogens, which replace the
carbon-hydrogen unit in the benzene ring. Based on nitrogen position present in the ring system, it is
categorized in three isomeric forms, i.e., 1, 2, 3-triazine (vicinal triazine), 1, 2, 4-triazine (asymmetrical
triazine or isotriazine) and 1, 3, 5-triazine (symmetrical or s-triazine or cyanidine). Triazines have
a weakly basic property. Their isomers have much weaker resonance energy than benzene structure, so
nucleophilic substitution reactions are more preferred than electrophilic substitution reactions. Triazine
isomers and their derivatives are known to play important roles possessing various activities in medicinal
and agricultural fields such as anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal,
antimalarial and antimicrobial agents.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Reference81 articles.
1. Yang R.; Kaplan P.A.; Reaction of isothiourea with 2, 3-diaza-3- pentenedioic anhydride: A solid-phase synthesis of 3-amino-1, 2, 4-triazin-5(4H)-ones. Tetrahedron Lett 2001,42,4433-4435
2. Hirai K.; Sugimoto H.; Mizushima T.J.; Triazinone derivative and antitumor agent JP: 61134389 A2, 1986
3. Oettmeier W.; Hilp U.; Draber W.; Fedtke C.; Schmidt R.R.; Structure-activity relationships of triazinone herbicides on resistant weeds and resistant chlamydomonas reinhardtii. Pesticidal Society 1991,33,399-409
4. Kranz E.; Santel H.; Luerssen K.; New 6-cyclo-butyl-1, 2, 4-triazinone derivs—useful as herbicides and plant growth regulators DE: 3917043 A1 1990
5. Migawa M.T.; Drach J.C.; Townsend L.B.; Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine. J Med Chem 2005,48(11),3840-3851
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