Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives-Reference-Cited by-同舟云学术

Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives

Published:2020-05-27 Issue:10 Volume:20 Page:818-830
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Manta Stella¹^ORCID,Kollatos Nikolaos¹^ORCID,Mitsos Christos¹^ORCID,Chatzieffraimidi Georgia-Anna¹^ORCID,Papanastasiou Ioannis²^ORCID,Gallos John K.³^ORCID,Komiotis Dimitri¹^ORCID

Affiliation:

1. Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, 41500, Larissa, Greece

2. Department of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece

3. Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

Abstract

Pyrrole is a very important pharmacophoric moiety. It has been widely incorporated into the skeleton of antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal active substances. Access to this key heterocycle by diverse routes is particularly attractive in terms of chemistry, and also from the environmental point of view. The present minireview summarizes the reported methods for the preparation of highly substituted pyrrole derivatives based on the one-pot multicomponent reaction of aldehydes, primary amines, and oxalacetate analogues as well as their biology.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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