Affiliation:
1. Department of Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151001, India
2. Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, 151001, India
Abstract
After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV),
infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands
the vigorous need of suitable anti-HIV agents, as existing medicines do not provide a complete
cure and exhibit drawbacks like toxicities, drug resistance, side-effects, etc. Even the introduction of
Highly Active Antiretroviral Therapy (HAART) failed to combat HIV/AIDS completely. The major
breakthrough in anti-HIV discovery was marked with the discovery of raltegravir in 2007, the first integrase
(IN) inhibitor. Thereafter, the discovery of elvitegravir, a quinolone derivative emerged as the
potent HIV-IN inhibitor. Though many more classes of different drugs that act as anti-HIV have been
identified, some of which are under clinical trials, but the recent serious focus is still laid on quinoline
and its analogues. In this review, we have covered all the quinoline-based derivatives that inhibit various
targets and are potential anti-HIV agents in various phases of the drug discovery.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
42 articles.
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