Carbocyclic Analogues of Distamycin and Netropsin
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Published:2018-12-06
Issue:2
Volume:19
Page:98-113
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ISSN:1389-5575
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Container-title:Mini-Reviews in Medicinal Chemistry
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language:en
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Short-container-title:MRMC
Author:
Arciszewska Karolina1, Pućkowska Anna2, Wróbel Agnieszka2, Drozdowska Danuta2
Affiliation:
1. Apteka Pod Gryfem, Bialystok 15-281, Legionowa Street 30/3, Poland 2. Department of Organic Chemistry, Medical University, Bialystok 15-222, Mickiewicza Street 2c, Poland
Abstract
The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability to interfere with biological processes such as enzyme catalysis, replication and transcription. The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-methylpyrrole-2-carboxylic acid residues, allowed to develop various DNA sequence-reading molecules, named lexitropsins, capable of interacting with DNA precisely, strongly and with a high specificity, and at the same time exhibiting significant cytotoxic potential. Among such compounds, lexitropsins built of carbocyclic sixmembered aromatic rings occupy a quite prominent place in drug research. This work is an attempt to present current findings in the study of carbocyclic lexitropins, their structures, syntheses and biological investigations such as DNA-binding and antiproliferative activity.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
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