Affiliation:
1. Department of Pharmaceutics, Qingdao University of Science and Technology, Qingdao 266042, China
2. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
Abstract
:
As important marine biological resources, corals produce a large amount of active organic
compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and
iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery
and research of important lead compounds and novel biological mechanisms. Through a large
number of literature surveys, this paper summarized a total of 145 halogenated secondary metabolites
which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids,
and they were mainly isolated from ten coral families, Ellisellidae, Gorgoniidae, Briareidae, Plexauridae,
Anthothelidae, Alcyoniidae, Clavularidae, Tubiporidae, Nephtheidae and Dendrophyllidae to the
best of our knowledge. In addition, their organism species, structure composition and biological activity
were also discussed in the form of a chart in this essay.
Funder
Shandong Provincial Natural Science Foundation for Distinguished Young Scholars
Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences
Key Research Program of Frontier Sciences, CAS
Key research and development project of Shandong province
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Reference78 articles.
1. Wen Z.; Guo Y.W.; Ernesto M.; Guido C.; Chemical studies on sesquiterpenes in soft coral Lobophytum sp. from the South China Sea. Nat Prod R 2005,17(6),740-725
2. Xiao-Hong A.I.; Chen Y.X.; Shu-Hua Q.I.; Recent progress in the chemical and pharmacological study of chinese corals. J Guangzhou Univ 2006,5,49-56
3. Ciereszko L.S.; Sifford D.H.; Weinheimer A.J.; Chemistry of coelenterates. I. Occurrence of terpenoid compounds in gorgonians. Ann N Y Acad Sci 1960,90(3),917
4. Weinheimer A.J.; Spraggins R.L.; The occurrence of two new prostaglandin derivatives (15-epi-PGA2 and its acetate, methyl ester) in the gorgonian Plexaura homomalla chemistry of coelenterates. XV. Tetrahedron Lett 1969,10(59),5185-5188
5. Shi Q.W.; Li-Geng L.I.; Huo C.H.; Zhang M.L.; Wang Y.F.; Research outline of marine natural products. Chin Tradit Herb Drugs 2010,41(7),1031-1047
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