Affiliation:
1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
Abstract
Tuberculosis (TB) takes the second place among the reasons for mortality from infectious
diseases. For this reason, the problem of tuberculosis treatment requires urgent attention all over the
world. Some 2-amino substituted 1,3-benzothiazin-4-ones (2-amino-1,3-BTZs) represent a promising
new class of antitubercular agents. Other 1,3-benzothiazin-4-one derivatives, mostly 2-aryl and 2-
(pyridin-2-yl) ones, are attractive due to their ability to suppress oxidative stress-induced cardiomyocyte
apoptosis. This review covers the synthetic approaches to 2-amino- and 2-aryl(heteryl) substituted
1,3-benzothiazin-4-ones (1,3-BTZs). A brief overview of structure-activity relationships is presented.
Funder
Ministry of Education and Science of Russian Federation
Russian Scientific Foundation
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
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