The Advances in Bioactivities, Mechanisms of Action and Structural Optimizations of Matrine and its Derivatives-Reference-Cited by-同舟云学术

The Advances in Bioactivities, Mechanisms of Action and Structural Optimizations of Matrine and its Derivatives

Published:2022-07 Issue:13 Volume:22 Page:1716-1734
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Lv Min¹,Xu Hui¹,Xu Jianwei¹

Affiliation:

1. College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, P.R. China

Abstract

Abstract: Matrine, a tetracyclo-quinolizidine alkaloid, is isolated from the industrial crop plant Sophora flavescens. Due to a wide range of pharmacological and agricultural properties, the research on the phytochemistry, pharmacology, toxicology, and mechanisms of action of matrine and its derivatives has received much attention. On the other hand, to improve their biological activities, the study on structural optimizations and structure-activity relationships of matrine and its derivatives has also attached more and more importance. In this review article, the updates regarding the advances in bioactivities, mechanisms of action, structural modifications, and structure-activity relationships of matrine and its derivatives from 2017 to 2020 are presented. We hope that this review will provide a reference for the development and application of matrine and its derivatives as drugs or pesticides in the future.

Funder

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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