Affiliation:
1. School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China
2. Key Laboratory of Ningxia Ethnomedicine
Modernization, Ministry of Education (Ningxia Medical University), Yinchuan, 750004, China
Abstract
Background:
Licorice is an important traditional Chinese medicine commonly used in
clinical practice and contains more than 300 flavonoids. Chalcone is one of the main types of flavonoids
with a wide range of biological functions and pharmacological activities. In the anticancer
research, chalcone compounds have shown excellent performance.
Objective:
This review aims to summarize the biosynthetic pathway and pharmacokinetics of chalcone
from licorice and provide evidence for the anticancer effects of chalcone and the underlying
mechanisms involved.
Methods:
For this review, the following databases were consulted: the PubMed Database
(https://pubmed.ncbi.nlm.nih.gov), Chinese National Knowledge Infrastructure (http://
www.cnki.net), National Science and Technology Library (http://www.nstl.gov.cn/), Wanfang Data
(http://www.wanfangdata.com.cn/), and the Web of Science Database (http://
apps.webofknowledge.com/).
Results:
To date, about 56 chalcones have been isolated and identified from licorice, 14 of which
have antitumor effects. These chalcones have a wide range of biological activities and can inhibit
the viability, proliferation, and migration of cancer cells by blocking the cancer cell cycle, thus inducing
apoptosis and autophagy. However, the molecular mechanism of the anticancer effects of
chalcone is not fully understood.
Conclusion:
In this paper, the molecular mechanism of chalcone regulating different types of cancer
is reviewed in detail from the biosynthetic pathway. This comprehensive review article summarizes
the biosynthetic pathway and pharmacokinetics of chalcone from the traditional Chinese medicine
licorice and provides evidence for the potential anticancer effects of chalcone and the respective
mechanisms of action. This paper also provides a basis for structural modification, biosynthesis, and
new drug development of chalcone compounds in Glycyrrhiza uralensis.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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