Affiliation:
1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China
Abstract
:
Ginsenosides, the essential active ingredients extracted from ginseng, have been well
studied in the past several decades because of their numerous pharmacological properties including
anti-tumor, anti-inflammatory, and anti-diabetic activities, as well as hepatoprotection, skin
protection, and memory improvement, etc. Compound-K (CK) is the major metabolite derived
from the deglycosylation of ginsenosides by intestinal bacteria and has been proved to be the actual
active entity absorbed into the systemic circulation. In this review, we comprehensively elucidate
the pharmacological activities of CK from the molecular mechanism, as well as its structurally
modified derivatives. We hope this review would be helpful to get a systematic summary and
provide constructive insights for the further research of CK.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine