An Overview of Treatment Guidelines and Methods of Synthesis of Drugs Used in Leprosy Chemotherapy-Reference-Cited by-同舟云学术

An Overview of Treatment Guidelines and Methods of Synthesis of Drugs Used in Leprosy Chemotherapy

Published:2023-03 Issue:4 Volume:23 Page:497-512
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Pinheiro Luiz C.S.¹^ORCID,Borges Julio C.²,Campos Vinicius R.³^ORCID,Dantas Leonardo C.³

Affiliation:

1. Departamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, São Gonçalo, RJ, Brazil

2. Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus Nilópolis, RJ, Brazil

3. Instituto de Química, Departamento de Química Orgânica, Universidade Federal Fluminense, Programa de Pós-Graduação em Química, Niterói, RJ, Brazil

Abstract

Abstract: Leprosy is a Neglected Tropical Disease (NTDs) caused by Mycobacterium leprae (M. leprae). The treatment is considered effective, however, the high dose Multidrug Therapy (MDT) for a long period and its adverse effects result in the abandonment of the treatment by patients. Indeed, antimicrobial resistance is still an obstacle that must be overcome in the treatment of leprosy. In the present article, we reviewed the WHO guidelines for the chemotherapy of leprosy and the methods of synthesis of these drugs.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Brasil

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

Reference88 articles.

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4. International Leprosy AssociationAvailable from: (Accessed on: September 09, 2021).

5. Regional office for south-east asia. ( 2018) . Guidelines for the diagnosis, treatment and prevention of leprosy. World health organization. Regional office for southeast asia. World health organization (WHO)Available from: (Accessed on: September 09, 2021).2018

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