Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases

Author:

Yew David T.123,Liu Congsheng4,Chen Zhiliang4,Wu Sharon L.Y.1,Chow Tony C.H.12,Cheng Rufina S.Y.1,Lee Jocy T.C.2

Affiliation:

1. School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Hong S.A.R., China

2. Hong Kong College of Technology, Hong Hong S.A.R., China

3. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Hong S.A.R., China

4. Fujian Provincial Corporate Key Laboratory of PTH Natural Medicine Research and Development (R & D), Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd., Fujian, China

Abstract

Abstract: The ancient composite formulae Angong Niuhuang pill and Pien Tze Huang, which were used a few hundred years ago to treat febrile disease and inflammation, respectively, are found to exert effects benefiting other neurological diseases and conditions. This short review introduces the main constituents of the two formulae, looking into both the cumulative synergetic and possible individual effects of each herb or animal apcoien. In essence, the main effects of Angong Niuhuang pill include anti-inflammation, antioxidation, anti-cell death, anticonvulsion, antiedema, antipyretic, antithrombotic, antimicrobial (bacteria, viruses, fungi), neuroprotective effects, and cardiovascular protection. The main effects of Pien Tze Huang include anti-inflammation, antioxidation, anti-cell death, antithrombotic, antimicrobial, neuroprotective effects, and cardiovascular protection. Comparing both composites, similarities in the effects and part of the components are found, showing some pharmacological evidence. This review casts light on research on the effects of neuroprotective and cardiovascular protective mechanisms as well as treatment mechanisms for cerebral accidents from the integrative medicine perspective.

Funder

Fujian Natural Science Foundation, China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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