Affiliation:
1. Research Institute of Pesticidal Design & Synthesis, College of Plant Protection/College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi Province, China
Abstract
Cytisine is a quinolizidine alkaloid isolated from various Leguminosae plants. Cytisine and
its derivatives exhibit a broad range of biological properties, such as smoking cessation aid, antidepressant,
neuroprotective, nootropic, anticancer, antiviral, antiparasitic, antidiabetic, insecticidal, and nematicidal
activities. In this review, the progress of cytisine and its derivatives in regard to bioactivities,
total synthesis, structural modifications focusing on their N-12 position and lactam ring is reported.
Additionally, the structure-activity relationships of cytisine and its derivatives are also discussed.
Funder
National Natural Science Foundation of China
Special Funds of Central Colleges Basic Scientific Research Operating Expenses, Northwest A&F University
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
13 articles.
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