Affiliation:
1. Organic Synthesis and Molecular Engineering Lab, Department of Chemistry, National Institute of Technology,
Rourkela 769008, India
Abstract
Abstract:
Severe Acute Respiratory Syndrome (SARS) aka SARS-CoV spread over southern China
for the first time in 2002-2003 and history repeated again since last year and took away lives of more
than two million people so far. On March 11, 2020 COVID-19 outbreak was officially declared as
pandemic by World Health Organization (WHO). The entire world united to fight back against this
ultimate destruction. Around 90 vaccines are featured against SARS-CoV-2 and more than 300 active
clinical trials are underway by several groups and individuals. So far, no drugs have been currently
approved that can completely eliminate the deadly coronavirus. The promising SARS-CoV-2 antiviral
drugs are favipiravir, remdesivir, lopinavir, ribavirin and avifavir. In this review, we have discussed
the synthetic approaches elaborately made so far by different groups and chemical companies
all around the world towards top three convincing anti-viral drugs against SARS-CoV-2, which are
favipiravir, remdesivir and lopinavir.
Funder
Department of Science and Technology (DST) India
INSPIRE-DST Government of India
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
1 articles.
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