Affiliation:
1. Division of Organic Chemistry and Biochemistry, Rudjer Bošković Institute, Bijenička 54, HR-10000 Zagreb, Croatia
Abstract
:
Among many reactive oxygen species (ROS) which are constantly generated during oxidative stress in cellular
membranes, formation and subsequent reactivity of ubiquitous 4-hydroxy-2-nonenal (HNE) with nearby amino acids and
lipids represents one of the main research targets in cell physiology in the last decades. Starting from the first synthesis of
HNE in 1967, chemistry and reactivity of HNE are constantly under intense scrutiny. This review shows recent advances in
the field which are discussed with the special emphasis on revealing intricate details of numerous reaction mechanisms of
HNE with lipids and amino acids, with the goal of understanding the reactivity of HNE at the molecular level.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
3 articles.
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