Affiliation:
1. Department of Neuroimaging and Interventional Radiology (NIIR), National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru-560 029, India
Abstract
Galectin-1 (Gal-1), a 14kDa carbohydrate-binding protein of the galectin family found in
humans, affects intracellular signaling pathways upon interaction with β-galactosides on cell-surface,
cytosol, and nucleus. The structural information reveals that it consists of a monovalent dimer composed
of subunits with one Carbohydrate Recognition Domain (CRD), which is the main active site to
interact with various glycoproteins, and carbohydrates in the body to regulate cellular functions. Gal-1
contributes towards different events associated with cancer biology, including tumor transformation,
cell cycle regulation, apoptosis, cell adhesion, migration, and inflammation. The extracellular existence
and function of Gal-1 have been well-established, and it is known to express in many tumor
types, including astrocytoma, melanoma, prostate, colon, bladder, and ovarian carcinomas, etc. Several
studies suggested the upregulation of Gal-1 levels in multiple cancer cells. Thus, Gal-1 is a promising
molecular target for the development of new therapeutic tools. The present review focuses on the
functions of Gal-1 in tumor progression in multiple cancers and its structural insights.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
13 articles.
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