Recent Update on the Anti-infective Potential of β-carboline Analogs-Reference-Cited by-同舟云学术

Recent Update on the Anti-infective Potential of β-carboline Analogs

Published:2021-02-16 Issue:4 Volume:21 Page:398-425
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Faheem ¹,Kumar Banoth Karan¹,Sekhar Kondapalli Venkata Gowri Chandra²,Kunjiappan Selvaraj³,Jamalis Joazaizulfazli⁴,Balaña-Fouce Rafael⁵,Sankaranarayanan Murugesan¹

Affiliation:

1. Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Vidya Vihar, Pilani-333031, Rajasthan, India

2. Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, R.R. Dist. Hyderabad, 500078, Telangana, India

3. Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil 626126, India

4. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia

5. Department of Biomedical Sciences; University of Leon, 24071 Leon, Spain

Abstract

β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

Funder

Ministerio de Economía y Competitividad (MINECO

Department of Biotechnology Indo-Spain

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

Reference116 articles.

1. Kotra L.P.; Infectious Diseases Elsevier; Enna, SJ 2007,1-2

2. Mehand M.S.; Al-Shorbaji F.; Millett P.; Murgue B.; The WHO R

3. Jones K.E.; Patel N.G.; Levy M.A.; Storeygard A.; Balk D.; Gittleman J.L.; Daszak P.; Global trends in emerging infectious diseases. Nature 2008,451(7181),990-993

4. Nii-Trebi N.I.; Emerging and Neglected Infectious Diseases: Insights, advances, and challenges. BioMed Res Int 2017

5. Zumla A.; Rao M.; Wallis R.S.; Kaufmann S.H.E.; Rustomjee R.; Mwaba P.; Vilaplana C.; Yeboah-Manu D.; Chakaya J.; Ippolito G.; Azhar E.; Hoelscher M.; Maeurer M.; Host-Directed Therapies Network consortium. Host-directed therapies for infectious diseases: Current status, recent progress, and future prospects. Lancet Infect Dis 2016,16(4),e47-e63

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and biological evaluation of novel 1,2,3,4-tetrahydro-β-carboline derivatives as potential antibacterial agents;Bioorganic & Medicinal Chemistry Letters;2024-09

2. Discovery and identification of natural alkaloids with potential to impact insulin resistance syndrome in Cyclocarya paliurus. (Batal) leaves by UPLC-QTOF-MS combined with HepG2 cells;Food Research International;2024-08

3. An updates: Oxidative aromatization of THβC to β-carbolines and their application for the β-carboline alkaloids synthesis;Tetrahedron;2024-04

4. New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation;Journal of Molecular Structure;2023-07

5. 3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents;Pharmaceuticals;2022-12-03