Medicinal Importance of Azo and Hippuric Acid Derivatives-Reference-Cited by-同舟云学术

Medicinal Importance of Azo and Hippuric Acid Derivatives

Published:2019-05-06 Issue:9 Volume:19 Page:708-719
ISSN:1389-5575
Container-title:Mini-Reviews in Medicinal Chemistry
language:en
Short-container-title:MRMC

Author:

Tahir Tehreem¹,Ashfaq Muhammad¹,Asghar Humna¹,Shahzad Mirza I.²,Tabassum Rukhsana³,Ashfaq Areeba⁴

Affiliation:

1. Department of Biochemistry and Biotechnology, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

2. University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

3. Department of Chemistry, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

4. Bahawal Victoria Hospital, Bahawalpur 63100, Pakistan

Abstract

In this review, specific therapeutic and medicinal advantages including antiviral, antibacterial, antifungal and antitumor, strategies for drug designing, structure-activity relationship, advances in the syntheses of azo and hippuric acid derivatives of more than 50 compounds have been discussed since 2009-2018. It is found that phenyl-diazenyl azo derivatives and pyridinyl substituted hippuric acid derivatives showed promising antiretroviral potential. The incorporation of azo functionality to the respective quinolones and coumarin moieties and the insertion of thiocarbazone to hippuric acid displayed immense antibacterial activities. While, azo and hippuric acid derivatives of triazole and phenyl species gave maximum fungicidal as well as cytotoxic activities.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology,General Medicine

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