Affiliation:
1. Nanyang Technological University, Singapore
2. Department of Chemistry, Cooch Behar Panchanan Barma University, Panchanan Nagar, Cooch Behar 736101, India
Abstract
COVID-19 is a public health emergency of international concern. Although considerable
knowledge has been acquired with time about the viral mechanism of infection and mode of replication,
yet no specific drugs or vaccines have been discovered against SARS-CoV-2 to date. There are
few small molecule antiviral drugs like Remdesivir and Favipiravir, which have shown promising results
in different advanced stages of clinical trials. Chloroquinine, Hydroxychloroquine, and Lopinavir-
Ritonavir combination, although initially were hypothesized to be effective against SARSCoV-
2, are now discontinued from the solidarity clinical trials. This review provides a brief description
of their chemical syntheses along with their mode of action, and clinical trial results available on
Google and in different peer-reviewed journals till 24th October 2020.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
8 articles.
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